The exact date when the building housing the St. Regis Hotel and Tavern was built is unknown. What is known is the building has been a combination hotel and tavern since 1883. The present name, St. Regis, goes back 91 years to 1931.
Sadly, a business that survived the Great Depression could not beat COVID. The St. Regis closed two years ago in mid March 2020. From the looks of it today, it seems rather doubtful that it will ever reopen.